Harrison Stratton, PhD

Publications

  1. Stratton HJ, Dolatyari M, Kopruszinski C, Ghetti A, Maciuba S, Bowden G, Rivière P, Barber K, Dodick DW, Edorh E, Dumaire N, Moutal A, Navratilova E, Porreca F. A prolactin-targeting antibody to prevent stress-induced peripheral nociceptor sensitization and female postoperative pain. Proc Natl Acad Sci U S A. 2025 May 20;122(20):e2501229122. doi: 10.1073/pnas.2501229122. Epub 2025 May 12. PMID: 40354542; PMCID: PMC12107140.
  2. Martin LF, Almuslim M, Ismail KA, Ibrahim MM, Moutal A, Cheng K, Stratton HJ, Price TJ, Vanderah TW, Olivera BM, Khanna R, Patwardhan A. The conotoxin Contulakin-G reverses hypersensitivity observed in rodent models of cancer-induced bone pain without inducing tolerance or motor disturbance. Pain. 2025 Feb 1;166(2):376-387. doi: 10.1097/j.pain.0000000000003391. Epub 2024 Sep 19. PMID: 39297754; PMCID: PMC11723812.
  3. Stratton H, Lee G, Dolatyari M, Ghetti A, Cotta T, Mitchell S, Yue X, Ibrahim M, Dumaire N, Salih L, Moutal A, François-Moutal L, Martin L, Navratilova E, Porreca F. Nociceptors are functionally male or female: from mouse to monkey to man. Brain. 2024 Dec 3;147(12):4280-4291. doi: 10.1093/brain/awae179. PMID: 38829801; PMCID: PMC11629683.
  4. Martin L*, Stratton HJ* (Co-First), Gomez K, Le Duy D, Loya-Lopez S, Tang C, Calderon- Rivera A, Ran D, Nunna V, Bellampalli SS, François-Moutal L, Dumaire N, Salih L, Luo S, Porreca F, Ibrahim M, Rogemond V, Honnorat J, Khanna R, Moutal A. Mechanism, and treatment of anti-CV2/CRMP5 autoimmune pain. bioRxiv [Preprint]. 2024 May 7:2024.05.04.592533. doi: 10.1101/2024.05.04.592533. PMID: 38766071; PMCID: PMC11100598. (Accepted – Nature Communications)
  5. Chen H, Bleimeister IH, Nguyen EK, Li J, Cui AY, Stratton HJ, Smith KM, Baccei ML, Ross SE. The functional and anatomical characterization of three spinal output pathways of the anterolateral tract. Cell Rep. 2024 Mar 26;43(3):113829. doi:10.1016/j.celrep.2024.113829. Epub 2024 Feb 28. PMID: 38421871; PMCID: PMC11025583.
  6. Maciuba S, Bowden GD, Stratton HJ, Wisniewski K, Schteingart CD, Almagro JC, Valadon P, Lowitz J, Glaser SM, Lee G, Dolatyari M, Navratilova E, Porreca F, Rivière PJM. Discovery and characterization of prolactin neutralizing monoclonal antibodies for the treatment of female-prevalent pain disorders. MAbs. 2023 Jan- Dec;15(1):2254676. doi: 10.1080/19420862.2023.2254676. PMID: 37698877; PMCID: PMC10498814.
  7. Gomez K, Stratton HJ, Duran P, Loya S, Tang C, Calderon-Rivera A, François-Moutal L, Khanna M, Madura CL, Luo S, McKiver B, Choi E, Ran D, Boinon L, Perez- Miller S, Damaj MI, Moutal A, Khanna R. Identification and targeting of a unique Na<sub>V</sub>1.7 domain driving chronic pain. Proc Natl Acad Sci U S A. 2023 Aug 8;120(32):e2217800120. doi: 10.1073/pnas.2217800120. Epub 2023 Jul 27. PMID:37498871; PMCID: PMC10410761.
  8. Stratton HJ, Boinon L, Gomez K, Martin L, Duran P, Ran D, Zhou Y, Luo S, Perez-Miller S, Patek M, Ibrahim MM, Patwardhan A, Moutal A, Khanna R. Targeting the vascular endothelial growth factor A/neuropilin 1 axis for relief of neuropathic pain. Pain. 2023 Jul 1;164(7):1473-1488. doi: 10.1097/j.pain.0000000000002850. Epub 2022 Dec 19. PMID: 36729125; PMCID: PMC10277229.
  9. Calderon-Rivera A, Gomez K, Loya-López S, Wijeratne EMK, Stratton H, Tang C, Duran P, Masterson K, Alsbiei O, Gunatilaka AAL, Khanna R. Betulinic acid analogs inhibit N- and T-type voltage-gated calcium channels to attenuate nerve-injury associated neuropathic and formalin models of pain. Neurobiol Pain. 2023 Jan 14;13:100116. doi: 10.1016/j.ynpai.2023.100116. PMID: 36687466; PMCID: PMC9853350.
  10. Quach TT, Stratton HJ, Khanna R, Mackey-Alfonso S, Deems N, Honnorat J, Meyer K, Duchemin AM. Neurodegenerative Diseases: From Dysproteostasis, Altered Calcium Signalosome to Selective Neuronal Vulnerability to AAV-Mediated Gene Therapy. Int J Mol Sci. 2022 Nov 16;23(22):14188. doi: 10.3390/ijms232214188. PMID: 36430666; PMCID: PMC9694178.
  11. Korah HE, Cheng K, Washington SM, Flowers ME, Stratton HJ, Patwardhan A, Ibrahim MM, Martin LF. Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies. J Vis Exp. 2022 Oct 6;(188). doi: 10.3791/64555. PMID: 36282702.
  12. Duran P, Loya-López S, Ran D, Tang C, Calderon-Rivera A, Gomez K, Stratton HJ, Huang S, Xu YM, Wijeratne EMK, Perez-Miller S, Shan Z, Cai S, Gabrielsen AT, Dorame A, Masterson KA, Alsbiei O, Madura CL, Luo G, Moutal A, Streicher J, Zamponi GW, Gunatilaka AAL, Khanna R. The natural product argentatin C attenuates postoperative pain via inhibition of voltage-gated sodium and T-type voltage-gated calcium channels. Br J Pharmacol. 2023 May;180(9):1267-1285. doi:10.1111/bph.15974. Epub 2023 Jan 15. PMID: 36245395.
  13. Gomez K, Tang C, Tan B, Perez-Miller S, Ran D, Loya S, Calderon-Rivera A, Stratton HJ, Duran P, Masterson KA, Gabrielsen AT, Alsbiei O, Dorame A, Serafini M, Moutal A, Wang J, Khanna R. Stereospecific Effects of Benzimidazolonepiperidine Compounds on T-Type Ca<sup>2+</sup> Channels and Pain. ACS Chem Neurosci. 2022 Jul 6;13(13):2035-2047. doi:10.1021/acschemneuro.2c00256. Epub 2022 Jun 7. PMID: 35671441.
  14. Braden K, Stratton HJ, Salvemini D, Khanna R. Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces and prevents pain chronification in a mouse model of oxaliplatin-induced neuropathic pain. Neurobiol Pain. 2021 Dec 27;11:100082. doi: 10.1016/j.ynpai.2021.100082. PMID:35024498; PMCID: PMC8733339.
  15. Li J, Stratton HJ, Lorca SA, Grace PM, Khanna R. Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in chronic constriction injury (CCI) rats. Channels (Austin). 2022 Dec;16(1):1-8. doi:10.1080/19336950.2021.2023383. PMID: 34983286; PMCID: PMC8741281.
  16. Quach TT, Stratton HJ, Khanna R, Kolattukudy PE, Honnorat J, Meyer K, Duchemin AM. Intellectual disability: dendritic anomalies and emerging genetic perspectives. Acta Neuropathol. 2021 Feb;141(2):139-158. doi: 10.1007/s00401-020-02244-5. Epub 2020 Nov 23. PMID: 33226471; PMCID: PMC7855540.
  17. Moutal A, Martin LF, Boinon L, Gomez K, Ran D, Zhou Y, Stratton HJ, Cai S, Luo S, Gonzalez KB, Perez-Miller S, Patwardhan A, Ibrahim MM, Khanna R. SARS-CoV-2 spike protein co-opts VEGF-A/neuropilin-1 receptor signaling to induce analgesia. Pain. 2021 Jan;162(1):243-252. doi: 10.1097/j.pain.0000000000002097. PMID: 33009246; PMCID: PMC7737878.
  18. Stratton HJ, Khanna R. Sculpting Dendritic Spines during Initiation and Maintenance of Neuropathic Pain. J Neurosci. 2020 Sep 30;40(40):7578-7589. doi: 10.1523/JNEUROSCI.1664-20.2020. PMID: 32998955; PMCID: PMC7531544.
  19. Moutal A, Martin LF, Boinon L, Gomez K, Ran D, Zhou Y, Stratton HJ, Cai S, Luo S, Gonzalez KB, Perez-Miller S, Patwardhan A, Ibrahim MM, Khanna R. SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce analgesia. bioRxiv [Preprint]. 2020 Sep 14:2020.07.17.209288. doi: 10.1101/2020.07.17.209288. Update in: Pain. 2021 Jan;162(1):243-252. doi:10.1097/j.pain.0000000000002097. PMID: 32869019; PMCID: PMC7457601.
  20. Moutal A, Cai S, Yu J, Stratton HJ, Chefdeville A, Gomez K, Ran D, Madura CL, Boinon L, Soto M, Zhou Y, Shan Z, Chew LA, Rodgers KE, Khanna R. Studies on CRMP2 SUMOylation-deficient transgenic mice identify sex-specific Nav1.7 regulation in the pathogenesis of chronic neuropathic pain. Pain. 2020 Nov;161(11):2629-2651. doi: 10.1097/j.pain.0000000000001951. PMID: 32569093; PMCID: PMC7572581.
  21. Stratton H, Boinon L, Moutal A, Khanna R. Coordinating Synaptic Signaling with CRMP2. Int J Biochem Cell Biol. 2020 Jul;124:105759. doi:10.1016/j.biocel.2020.105759. Epub 2020 May 8. PMID: 32437854
  22. Stratton H, Khanna R. Just in time! Identification of a novel mechanism for treating PIPN. J Physiol. 2020 Jun;598(12):2283-2284. doi: 10.1113/JP279863. Epub 2020 May 12. PMID: 32266977; PMCID: PMC7299801.
  23. Xia KK, Lyu Y, Yuan WT, Wang GX, Stratton H, Zhang SJ, Wu J. Nanocarriers of Fe<sub>3</sub>O<sub>4</sub> as a Novel Method for Delivery of the Antineoplastic Agent Doxorubicin Into HeLa Cells <i>in vitro</i>. Front Oncol. 2019 Apr 10;9:250. doi: 10.3389/fonc.2019.00250. PMID: 31110964; PMCID: PMC6499231.
  24. Eaton JB, Lucero LM, Stratton H, Chang Y, Cooper JF, Lindstrom JM, Lukas RJ, Whiteaker P. The unique α4+/-α4 agonist binding site in (α4)3(β2)2 subtype nicotinic acetylcholine receptors permits differential agonist desensitization pharmacology versus the (α4)2(β2)3 subtype. J Pharmacol Exp Ther. 2014 Jan;348(1):46-58. doi: 10.1124/jpet.113.208389. Epub 2013 Nov 4. PMID: 24190916; PMCID: PMC3868879.
  25. Liu SB, Ma Z, Sun WL, Sun XW, Hong Y, Ma L, Qin C, Stratton HJ, Liu Q, Jiang JT. The role of androgen-induced growth factor (FGF8) on genital tubercle development in a hypospadiac male rat model of prenatal exposure to di-n-butyl phthalate. Toxicology. 2012 Mar 11;293(1-3):53-58. doi:10.1016/j.tox.2011.12.010. Epub 2012 Jan 17. PMID: 22273727.
  26. Jiang JT, Sun WL, Jing YF, Liu SB, Ma Z, Hong Y, Ma L, Qin C, Liu Q, Stratton HJ, Xia SJ. Prenatal exposure to di-n-butyl phthalate induces anorectal malformations in male rat offspring. Toxicology. 2011 Dec 18;290(2-3):322-6. doi: 10.1016/j.tox.2011.10.008. Epub 2011 Oct 18. PMID: 22027561.
  27. Carmona JE, Holland AK, Stratton HJ, Harrison DW. Sympathetic arousal to a vestibular stressor in high and low hostile men. Brain Cogn. 2008 Mar;66(2):150-5. doi: 10.1016/j.bandc.2007.06.004. Epub 2007 Aug 13. PMID:17706332.